Issue 45, 2015

Biotin-guided anticancer drug delivery with acidity-triggered drug release

Abstract

A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.

Graphical abstract: Biotin-guided anticancer drug delivery with acidity-triggered drug release

Supplementary files

Article information

Article type
Communication
Submitted
10 Apr 2015
Accepted
02 May 2015
First published
04 May 2015

Chem. Commun., 2015,51, 9343-9345

Biotin-guided anticancer drug delivery with acidity-triggered drug release

S. Park, E. Kim, W. Y. Kim, C. Kang and J. S. Kim, Chem. Commun., 2015, 51, 9343 DOI: 10.1039/C5CC03003J

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