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Issue 56, 2015
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A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids

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Abstract

A powerful strategy for the efficient lead-oriented synthesis of novel molecular scaffolds is demonstrated. Twenty two scaffolds were prepared from just four α-amino acid-derived building blocks and a toolkit of six connective reactions. Importantly, each individual scaffold has the ability to specifically target lead-like chemical space.

Graphical abstract: A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids

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Article information


Submitted
10 Apr 2015
Accepted
11 May 2015
First published
11 May 2015

This article is Open Access

Chem. Commun., 2015,51, 11174-11177
Article type
Communication
Author version available

A systematic approach to diverse, lead-like scaffolds from α,α-disubstituted amino acids

D. J. Foley, R. G. Doveston, I. Churcher, A. Nelson and S. P. Marsden, Chem. Commun., 2015, 51, 11174
DOI: 10.1039/C5CC03002A

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