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Issue 59, 2015
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Conformational cooperativity between helical domains of differing geometry in oligoamide–oligourea foldamer chimeras

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Abstract

Linking together an oligourea and an oligoamide foldamer gives rise to a conformationally well-defined structure, despite the different hydrogen-bonding patterns in the two domains, provided the oligomers are ligated amide C terminus to urea N terminus. A powerful screw-sense preference induced at the N terminus of the resulting chimeric structure provides evidence for cooperative conformational interactions within the ‘block co-foldamer’.

Graphical abstract: Conformational cooperativity between helical domains of differing geometry in oligoamide–oligourea foldamer chimeras

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Publication details

The article was received on 10 Apr 2015, accepted on 05 Jun 2015 and first published on 05 Jun 2015


Article type: Communication
DOI: 10.1039/C5CC02995C
Citation: Chem. Commun., 2015,51, 11802-11805
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    Conformational cooperativity between helical domains of differing geometry in oligoamide–oligourea foldamer chimeras

    J. Maury, B. A. F. Le Bailly, J. Raftery and J. Clayden, Chem. Commun., 2015, 51, 11802
    DOI: 10.1039/C5CC02995C

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