KOtBu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones

Abhimanyu Yadav; Ajay Verma; Saket Patel; Amit Kumar; Vandana Rathore; Meenakshi; Shailesh Kumar; Sangit Kumar

doi:10.1039/C5CC02964C

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KO^tBu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones

Abhimanyu Yadav, Ajay Verma, Saket Patel, Amit Kumar, Vandana Rathore, Meenakshi, Shailesh Kumar and Sangit Kumar
Chem. Commun., 2015,51, 11658-11661
DOI: 10.1039/C5CC02964C, Communication

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Abstract | Cited by

The KO^tBu-mediated annulation of acetonitrile with aldehyde was observed, in which the cleavage of four C(sp³)–H bonds occurred and a total of eight new bonds were formed during the synthesis of substituted dihydropyridinones in the presence of peroxide. Furthermore, dihydropyridinones have been transformed into pyridinones using KO^tBu in DMSO.

Graphical abstract: KOtBu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones

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