KOtBu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones

Abhimanyu Yadav; Ajay Verma; Saket Patel; Amit Kumar; Vandana Rathore; Meenakshi; Shailesh Kumar; Sangit Kumar

doi:10.1039/C5CC02964C

KO^tBu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones

Abhimanyu Yadav,^a Ajay Verma,^a Saket Patel,^a Amit Kumar,^a Vandana Rathore,^a Meenakshi,^a Shailesh Kumar^a and Sangit Kumar*^a

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* Corresponding authors

^a Department of Chemistry, Indian Institute of Science Education and Research (IISER) Bhopal, Indore By-pass Road, Bhauri, Bhopal, India
E-mail: sangitkumar@iiserb.ac.in

Abstract

The KO^tBu-mediated annulation of acetonitrile with aldehyde was observed, in which the cleavage of four C(sp³)–H bonds occurred and a total of eight new bonds were formed during the synthesis of substituted dihydropyridinones in the presence of peroxide. Furthermore, dihydropyridinones have been transformed into pyridinones using KO^tBu in DMSO.

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Publication details

The article was received on 09 Apr 2015, accepted on 04 Jun 2015 and first published on 04 Jun 2015

Article type: Communication

DOI: 10.1039/C5CC02964C

Citation: Chem. Commun., 2015,51, 11658-11661

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KO^tBu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones

A. Yadav, A. Verma, S. Patel, A. Kumar, V. Rathore, Meenakshi, S. Kumar and S. Kumar, Chem. Commun., 2015, 51, 11658
DOI: 10.1039/C5CC02964C

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Chemical Communications

KO^tBu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones

Abstract

Supplementary files

Publication details

KO^tBu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones

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