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Issue 46, 2015
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N-Heterocyclic carbene-catalyzed diastereoselective synthesis of β-lactone-fused cyclopentanes using homoenolate annulation reaction

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Abstract

NHC-catalyzed annulation of enals with 2-enoylpyridines or 2-enoylpyridine N-oxides leading to the diastereoselective synthesis of β-lactone-fused cyclopentanes is reported. The reaction proceeds via the generation of homoenolate equivalent intermediates and tolerates a broad range of functional groups.

Graphical abstract: N-Heterocyclic carbene-catalyzed diastereoselective synthesis of β-lactone-fused cyclopentanes using homoenolate annulation reaction

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The article was received on 09 Apr 2015, accepted on 07 May 2015 and first published on 07 May 2015


Article type: Communication
DOI: 10.1039/C5CC02960K
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Citation: Chem. Commun., 2015,51, 9559-9562
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    N-Heterocyclic carbene-catalyzed diastereoselective synthesis of β-lactone-fused cyclopentanes using homoenolate annulation reaction

    S. Mukherjee, S. Mondal, A. Patra, R. G. Gonnade and A. T. Biju, Chem. Commun., 2015, 51, 9559
    DOI: 10.1039/C5CC02960K

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