Binding or aggregation? Hazards of interpretation in studies of molecular recognition by porphyrins in water

Abstract

Reports have suggested that polar porphyrins such as tetraphenylporphine tetrasulfonate (TPPS) can serve as carbohydrate receptors in water. Here we find that TPPS shows changes in UV-visible absorption when treated with glucose, but that these are best explained by altered aggregation states and not by formation of a closely-bound complex.