Issue 59, 2015
From the journal:

Chemical Communications

Designed filamentous cell penetrating peptides: probing supramolecular structure-dependent membrane activity and transfection efficiency†

Dawei Xu,‡a   Derek Dustin,‡a   Linhai Jiang,a   Damien S. K. Samwaysb  and  He Dong*a  

* Corresponding authors

a Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, NY 13699, USA
E-mail: hdong@clarkson.edu

b Department of Biology, Clarkson University, Potsdam, NY 13699, USA

Abstract

In this work, we will demonstrate a simple yet powerful strategy to assemble single-chain cationic peptides into macromolecular filamentous nanostructures with dramatically improved membrane activity, stability and transfection efficiency.

Graphical abstract: Designed filamentous cell penetrating peptides: probing supramolecular structure-dependent membrane activity and transfection efficiency

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Article information

DOI
https://doi.org/10.1039/C5CC02699G
Article type
Communication
Submitted
01 Apr 2015
Accepted
29 May 2015
First published
29 May 2015

Chem. Commun., 2015,51, 11757-11760

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Designed filamentous cell penetrating peptides: probing supramolecular structure-dependent membrane activity and transfection efficiency

D. Xu, D. Dustin, L. Jiang, D. S. K. Samways and H. Dong, Chem. Commun., 2015, 51, 11757 DOI: 10.1039/C5CC02699G

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