Issue 56, 2015
From the journal:

Chemical Communications

Hydroamination of terminal alkynes with secondary amines catalyzed by copper: regioselective access to amines†

Janet Bahri,ab   Rémi Blieck,a   Bassem Jamoussi,b   Marc Taillefer*a  and  Florian Monnier*a  

* Corresponding authors

a Ecole Nationale Supérieure de Chimie de Montpellier, Institut Charles Gerhardt, CNRS UMR 5253, AM2N, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex 05, France
E-mail: marc.taillefer@enscm.fr, florian.monnier@enscm.fr

b Laboratoire de Chimie, Institut Supérieur d'Education et de Formation Continue, 43 Rue de la Liberté, Le Bardo, Tunisia

Abstract

A simple and convenient copper-catalyzed hydroamination of arylacetylenes with secondary amines has been performed giving a simple access to aliphatic amines after reduction of the hydroaminated products (E-enamines). Here we described a mild catalytic system utilizing CuCN precatalyst without any additive ligands in a solvent-free system.

Graphical abstract: Hydroamination of terminal alkynes with secondary amines catalyzed by copper: regioselective access to amines

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Article information

DOI
https://doi.org/10.1039/C5CC02677F
Article type
Communication
Submitted
31 Mar 2015
Accepted
06 Jun 2015
First published
16 Jun 2015

Chem. Commun., 2015,51, 11210-11212

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Hydroamination of terminal alkynes with secondary amines catalyzed by copper: regioselective access to amines

J. Bahri, R. Blieck, B. Jamoussi, M. Taillefer and F. Monnier, Chem. Commun., 2015, 51, 11210 DOI: 10.1039/C5CC02677F

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