Issue 50, 2015

Conjugation of polymers to proteins through an inhibitor-derived peptide: taking up the inhibitor “berth”

Abstract

A hexapeptide derived from an enzyme inhibitor was used as an affinity ligand for the conjugation of a hydrophilic polymer to the enzyme. The peptide targeted the polymer to the “berth” of the inhibitor in the enzyme, affording the enzyme resistance to the inhibitor without affecting the enzymatic activity.

Graphical abstract: Conjugation of polymers to proteins through an inhibitor-derived peptide: taking up the inhibitor “berth”

Supplementary files

Article information

Article type
Communication
Submitted
31 Mar 2015
Accepted
28 Apr 2015
First published
28 Apr 2015

Chem. Commun., 2015,51, 10099-10102

Conjugation of polymers to proteins through an inhibitor-derived peptide: taking up the inhibitor “berth”

Z. Tang, D. Li, Y. Luan, L. Zhu, H. Du, Y. Tao, Y. Wang, D. M. Haddleton and H. Chen, Chem. Commun., 2015, 51, 10099 DOI: 10.1039/C5CC02659H

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