Issue 41, 2015

A label-free fluorescent molecular switch for a DNA hybridization assay utilizing a G-quadruplex-selective auramine O

Abstract

A sensitive and selective assay of DNA is developed by utilizing a signal transduction strategy with the rational redesign of the hairpin structured G-quadruplex molecular switch (G4-MS) assembled using auramine O (AO). By monitoring the changes of the fluorescent signal, we could identify and further quantitatively determine the target DNA in the samples.

Graphical abstract: A label-free fluorescent molecular switch for a DNA hybridization assay utilizing a G-quadruplex-selective auramine O

Supplementary files

Article information

Article type
Communication
Submitted
30 Mar 2015
Accepted
15 Apr 2015
First published
15 Apr 2015

Chem. Commun., 2015,51, 8622-8625

Author version available

A label-free fluorescent molecular switch for a DNA hybridization assay utilizing a G-quadruplex-selective auramine O

H. Xu, F. Geng, Y. Wang, M. Xu, X. Lai, P. Qu, Y. Zhang and B. Liu, Chem. Commun., 2015, 51, 8622 DOI: 10.1039/C5CC02624E

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