Issue 40, 2015
From the journal:

Chemical Communications

Synthesis and anticancer properties of fucoidan-mimetic glycopolymer coated gold nanoparticles†

Mattias Tengdelius,‡ab   Deepanjali Gurav,‡cd   Peter Konradsson,ab   Peter Påhlsson,bf   May Griffithbef  and  Oommen P. Oommen*c  

* Corresponding authors

a Division of Organic Chemistry, Linköping University, Linköping, Sweden

b Integrative Regenerative Medicine Center (IGEN), Linköping University, Linköping, Sweden

c Department of Chemistry, Ångström Laboratory, Uppsala University, S-75121 Uppsala, Sweden
E-mail: oommen.op@kemi.uu.se

d Department of Chemistry, Savitri Bai Phule Pune University, India

e Division of Molecular Physics, Department of Physics, Biology and Chemistry (IFM), Linköping University, Linköping, Sweden

f Division of Cell Biology, Department of Clinical and Experimental Medicine (IKE), Linköping University, Linköping, Sweden

Abstract

Gold nanoparticles coated with fucoidan-mimetic glycopolymers were synthesized that displayed good colloidal stability and promising anti-cancer properties. Fucoidan mimetic glycopolymers on their own were nontoxic, while glycopolymer coated gold nanoparticles displayed selective cytotoxicity to human colon cancer cell lines (HCT116) while it was non-toxic to mouse fibroblast cells (NIH3T3).

Graphical abstract: Synthesis and anticancer properties of fucoidan-mimetic glycopolymer coated gold nanoparticles

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Article information

DOI
https://doi.org/10.1039/C5CC02387D
Article type
Communication
Submitted
22 Mar 2015
Accepted
10 Apr 2015
First published
10 Apr 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 8532-8535

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Synthesis and anticancer properties of fucoidan-mimetic glycopolymer coated gold nanoparticles

M. Tengdelius, D. Gurav, P. Konradsson, P. Påhlsson, M. Griffith and O. P. Oommen, Chem. Commun., 2015, 51, 8532 DOI: 10.1039/C5CC02387D

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