Photoinduced cytotoxicity of a photochromic diarylethene via caspase cascade activation

Jun-ya Okuda; Yukimi Tanaka; Ryuhei Kodama; Kimio Sumaru; Kana Morishita; Toshiyuki Kanamori; Seiji Yamazoe; Kengo Hyodo; Shohei Yamazaki; Tomohiro Miyatake; Satoshi Yokojima; Sinichiro Nakamura; Kingo Uchida

doi:10.1039/C5CC02200B

Photoinduced cytotoxicity of a photochromic diarylethene via caspase cascade activation†

Jun-ya Okuda,^a Yukimi Tanaka,^a Ryuhei Kodama,^a Kimio Sumaru,*^b Kana Morishita,^b Toshiyuki Kanamori,^b Seiji Yamazoe,^ac Kengo Hyodo,^a Shohei Yamazaki,^a Tomohiro Miyatake,^a Satoshi Yokojima,^de Sinichiro Nakamura^e and Kingo Uchida*^a

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^a Department of Materials Chemistry, Faculty of Science and Technology, Ryukoku University, Seta, Otsu, Shiga 520-2194, Japan
E-mail: uchida@rins.ryukoku.ac.jp
Fax: +81-77-543-7483
Tel: +81-77-543-7462

^b Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5th, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan
E-mail: k.sumaru@aist.go.jp
Fax: +81 29 861 6278
Tel: +81 29 861 6373

^c Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

^d School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

^e RIKEN Research Cluster for Innovation, Nakamura Laboratory, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Abstract

The photo-generated closed-ring isomer of bis(5-methyl-2-phenylthiazoyl)perfluorocyclopentene shows cytotoxicity to Madin–Darby canine kidney (MDCK) cells through a caspase cascade and induces apoptosis of cells.

Chemical Communications

Photoinduced cytotoxicity of a photochromic diarylethene via caspase cascade activation†

Abstract

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Photoinduced cytotoxicity of a photochromic diarylethene via caspase cascade activation

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