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Issue 40, 2015
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Tailoring highly branched poly(β-amino ester)s: a synthetic platform for epidermal gene therapy

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Abstract

Highly branched poly(β-amino ester)s (HPAEs) were designed and synthesised for safe and efficient gene delivery to human keratinocytes. HPAEs outperformed commercial transfection reagents: PEI and SuperFect®, for both transfection efficiency and biocompatibility. A 22 and 3.4 fold enhancement of gene transfection was seen coupled with superior biocompatibility.

Graphical abstract: Tailoring highly branched poly(β-amino ester)s: a synthetic platform for epidermal gene therapy

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Supplementary files

Article information


Submitted
15 Mar 2015
Accepted
13 Apr 2015
First published
14 Apr 2015

Chem. Commun., 2015,51, 8473-8476
Article type
Communication

Tailoring highly branched poly(β-amino ester)s: a synthetic platform for epidermal gene therapy

J. Huang, Y. Gao, L. Cutlar, J. O'Keeffe-Ahern, T. Zhao, F. Lin, D. Zhou, S. McMahon, U. Greiser, W. Wang and W. Wang, Chem. Commun., 2015, 51, 8473
DOI: 10.1039/C5CC02193F

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