A novel concept that target DNA can induce switching of DNA polymerase activity is devised. The method relies on the finding that a DNA aptamer can undergo conformational change upon hybridization with a complementary target DNA, which leads to activation or inactivation of DNA polymerase. This strategy is utilized to identify the presence of target DNA with high levels of sensitivity and selectivity.
K. S. Park, C. Y. Lee and H. G. Park, Chem. Commun., 2015, 51, 9942 DOI: 10.1039/C5CC02060C
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