Issue 43, 2015

Cucurbit[6]uril is an ultrasensitive 129Xe NMR contrast agent

Abstract

A lack of molecular contrast agents has slowed the application of ultrasensitive hyperpolarized 129Xe NMR methods. Here, we report that commercially available cucurbit[6]uril (CB[6]) undergoes rapid xenon exchange kinetics at 300 K, and is detectable by Hyper-CEST NMR at 1.8 pM in PBS and at 1 μM in human plasma where many molecules, including polyamines, can compete with xenon for CB[6] binding.

Graphical abstract: Cucurbit[6]uril is an ultrasensitive 129Xe NMR contrast agent

Supplementary files

Article information

Article type
Communication
Submitted
03 Mar 2015
Accepted
21 Apr 2015
First published
21 Apr 2015

Chem. Commun., 2015,51, 8982-8985

Author version available

Cucurbit[6]uril is an ultrasensitive 129Xe NMR contrast agent

Y. Wang and I. J. Dmochowski, Chem. Commun., 2015, 51, 8982 DOI: 10.1039/C5CC01826A

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