Issue 41, 2015
From the journal:

Chemical Communications

The effect of amorphous calcium phosphate on protein protection against thermal denaturation†

Yuling Yang,a   Guangchuan Wang,b   Genxing Zhu,a   Xurong Xu,b   Haihua Panb  and  Ruikang Tang*ab  

* Corresponding authors

a Centre for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China
E-mail: rtang@zju.edu.cn

b Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, Zhejiang 310027, China

Abstract

The hybrid nanoparticles of amorphous calcium phosphate (ACP)–catalase (CAT) developed by in situ biomineralization can create a stable semi-aqueous nanoscale environment for entrapped proteins against thermal denaturation. This finding indicates the importance of an amorphous mineral phase in the preservation of organic macromolecules.

Graphical abstract: The effect of amorphous calcium phosphate on protein protection against thermal denaturation

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Article information

DOI
https://doi.org/10.1039/C5CC01420D
Article type
Communication
Submitted
15 Feb 2015
Accepted
20 Apr 2015
First published
20 Apr 2015

Chem. Commun., 2015,51, 8705-8707

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The effect of amorphous calcium phosphate on protein protection against thermal denaturation

Y. Yang, G. Wang, G. Zhu, X. Xu, H. Pan and R. Tang, Chem. Commun., 2015, 51, 8705 DOI: 10.1039/C5CC01420D

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