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Issue 34, 2015
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DNA polymerase-catalyzed incorporation of nucleotides modified with a G-quadruplex-derived DNAzyme

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Abstract

We show that nucleotides which are modified with a G-quadruplex-derived DNAzyme are substrates for DNA polymerases. Based on this finding we developed a naked-eye detection system that allows the detection of single nucleotide variations in DNA.

Graphical abstract: DNA polymerase-catalyzed incorporation of nucleotides modified with a G-quadruplex-derived DNAzyme

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Publication details

The article was received on 13 Feb 2015, accepted on 18 Mar 2015 and first published on 25 Mar 2015


Article type: Communication
DOI: 10.1039/C5CC01387A
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Citation: Chem. Commun., 2015,51, 7379-7381

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    DNA polymerase-catalyzed incorporation of nucleotides modified with a G-quadruplex-derived DNAzyme

    D. Verga, M. Welter, A.-L. Steck and A. Marx, Chem. Commun., 2015, 51, 7379
    DOI: 10.1039/C5CC01387A

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