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Issue 36, 2015
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Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids

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Abstract

Here we report the discovery of a cytochrome P450 that is required for the biosynthesis of vindoline, a plant-derived natural product used for semi-synthesis of several anti-cancer drugs. This enzyme catalyzes the formation of an epoxide that can undergo rearrangement to yield the vincamine–eburnamine backbone, thereby providing evidence for the long-standing hypothesis that the aspidosperma- and eburnamine-type alkaloids are biosynthetically related.

Graphical abstract: Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids

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Supplementary files

Article information


Submitted
11 Feb 2015
Accepted
19 Mar 2015
First published
19 Mar 2015

Chem. Commun., 2015,51, 7626-7628
Article type
Communication
Author version available

Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids

F. Kellner, F. Geu-Flores, N. H. Sherden, S. Brown, E. Foureau, V. Courdavault and S. E. O'Connor, Chem. Commun., 2015, 51, 7626
DOI: 10.1039/C5CC01309G

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