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Issue 61, 2015
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Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers

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Abstract

A series of pH and GSH responsive photosensitizers were designed and synthesized. pKa values were optimized by adjusting the inductive contribution of substituents to reach a pH range (6.0–7.4) relevant to the tumour microenvironment. pH-Activatable behaviour and redox mediated release of the quencher from the PS by GSH allow the construction of an AND logic operator for selective photodynamic action in aqueous solutions.

Graphical abstract: Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers

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Publication details

The article was received on 10 Feb 2015, accepted on 22 Jun 2015 and first published on 22 Jun 2015


Article type: Communication
DOI: 10.1039/C5CC01261A
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Citation: Chem. Commun., 2015,51, 12258-12261

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    Selective photosensitization through an AND logic response: optimization of the pH and glutathione response of activatable photosensitizers

    S. Erbas-Cakmak, F. P. Cakmak, S. D. Topel, T. B. Uyar and E. U. Akkaya, Chem. Commun., 2015, 51, 12258
    DOI: 10.1039/C5CC01261A

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