Issue 45, 2015

N-Heterocyclic carbene-catalyzed [2+3] cyclocondensation of α-chloroaldehydes with azomethine imines

Abstract

An N-heterocyclic carbene-catalyzed enantioselective [2+3] cyclocondensation of α-chloroaldehydes with azomethine imines was developed. The corresponding pyrazolidinones were obtained in good yields with moderate to good diastereoselectivities and excellent enantioselectivities.

Graphical abstract: N-Heterocyclic carbene-catalyzed [2+3] cyclocondensation of α-chloroaldehydes with azomethine imines

Supplementary files

Article information

Article type
Communication
Submitted
10 Feb 2015
Accepted
04 May 2015
First published
04 May 2015

Chem. Commun., 2015,51, 9328-9331

Author version available

N-Heterocyclic carbene-catalyzed [2+3] cyclocondensation of α-chloroaldehydes with azomethine imines

Z. Gao, X. Chen, J. Cheng, W. Liao and S. Ye, Chem. Commun., 2015, 51, 9328 DOI: 10.1039/C5CC01238D

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