Issue 31, 2015
From the journal:

Chemical Communications

Polypyrrole nanoprobes with low non-specific protein adsorption for intracellular mRNA detection and photothermal therapy†

Kaimei Ke,a   Lisen Lin,a   Hong Liang,a   Xian Chen,a   Chao Han,b   Juan Li*a  and  Huang-Hao Yanga  

* Corresponding authors

a The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou 350002, P. R. China
E-mail: lijuanfzu@gmail.com

b Wenzhou Entry-Exit Inspection and Quarantine Bureau of P.R.C, Wenzhou 325027, P. R. China

Abstract

In this work, we discovered that polypyrrole nanoparticles (PPy NPs) displayed a low non-specific protein adsorption. We herein present the first PPy NP-based biosensing platform for intracellular mRNA detection in living cells. We also demonstrate that PPy NPs exhibit high NIR absorbance and can be utilized for cancer photothermal therapy.

Graphical abstract: Polypyrrole nanoprobes with low non-specific protein adsorption for intracellular mRNA detection and photothermal therapy

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Article information

DOI
https://doi.org/10.1039/C5CC01129A
Article type
Communication
Submitted
06 Feb 2015
Accepted
11 Mar 2015
First published
11 Mar 2015

Chem. Commun., 2015,51, 6800-6803

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Polypyrrole nanoprobes with low non-specific protein adsorption for intracellular mRNA detection and photothermal therapy

K. Ke, L. Lin, H. Liang, X. Chen, C. Han, J. Li and H. Yang, Chem. Commun., 2015, 51, 6800 DOI: 10.1039/C5CC01129A

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