Issue 30, 2015
From the journal:

Chemical Communications

DNA-templated in situ growth of AgNPs on SWNTs: a new approach for highly sensitive SERS assay of microRNA†

Jing Zheng,‡a   Junhui Bai,‡a   Qifeng Zhou,a   Jishan Li,a   Yinhui Li,a   Jinfeng Yangb  and  Ronghua Yang*ac  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China
E-mail: Yangrh@pku.ed.cn

b Department of Anesthesiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China

c School of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha, China

Abstract

In this communication, we find that the single-walled carbon nanotubes (SWNTs) can demonstrate an excellent ssDNA concentration-dependent surface enhanced Raman scattering (SERS) effect after the decoration of DNA-templated in situ grown AgNPs on the surface. Inspired by this, the SWNT@AgNPs hybrid nanocomposite was employed to achieve microRNA detection which is also sensitive to crude extraction from human breast cancer cells and even patient tissues before and after chemotherapy.

Graphical abstract: DNA-templated in situ growth of AgNPs on SWNTs: a new approach for highly sensitive SERS assay of microRNA

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Article information

DOI
https://doi.org/10.1039/C5CC01003A
Article type
Communication
Submitted
04 Feb 2015
Accepted
25 Feb 2015
First published
25 Feb 2015

Chem. Commun., 2015,51, 6552-6555

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DNA-templated in situ growth of AgNPs on SWNTs: a new approach for highly sensitive SERS assay of microRNA

J. Zheng, J. Bai, Q. Zhou, J. Li, Y. Li, J. Yang and R. Yang, Chem. Commun., 2015, 51, 6552 DOI: 10.1039/C5CC01003A

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