Issue 30, 2015
From the journal:

Chemical Communications

DNA-templated in situ growth of silver nanoparticles on mesoporous silica nanospheres for smart intracellular GSH-controlled release†

Changhui Liu,ab   Zhihe Qing,c   Jing Zheng,a   Li Deng,a   Cheng Ma,a   Jishan Li,a   Yinhui Li,a   Sheng Yang,ac   Jinfeng Yang,d   Jing Wang,d   Weihong Tanae  and  Ronghua Yang*ac  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha, P. R. China
E-mail: yangrh@hnu.edu.cn
Fax: +86-731-88822523
Tel: +86-731-88822523

b Department of Chemistry and Environmental Engineering, Hunan City University, Yiyang, P. R. China

c School of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha, P. R. China

d The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, P. R. China

e Center for Research at the Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USA

Abstract

In this work, we propose a method for constructing silver nanoparticles (AgNPs) on mesoporous silica nanospheres (MSNs) by a DNA-templated process. By in situ formation, the gatekeeper can be easily modulated to meet different degrees of glutathione (GSH) stimuli for location-specific drug release.

Graphical abstract: DNA-templated in situ growth of silver nanoparticles on mesoporous silica nanospheres for smart intracellular GSH-controlled release

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Article information

DOI
https://doi.org/10.1039/C5CC00557D
Article type
Communication
Submitted
20 Jan 2015
Accepted
02 Mar 2015
First published
02 Mar 2015

Chem. Commun., 2015,51, 6544-6547

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DNA-templated in situ growth of silver nanoparticles on mesoporous silica nanospheres for smart intracellular GSH-controlled release

C. Liu, Z. Qing, J. Zheng, L. Deng, C. Ma, J. Li, Y. Li, S. Yang, J. Yang, J. Wang, W. Tan and R. Yang, Chem. Commun., 2015, 51, 6544 DOI: 10.1039/C5CC00557D

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