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Issue 29, 2015
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Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator

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Abstract

In this study we demonstrate that linifanib, a multi-targeted receptor tyrosine kinase inhibitor, with a key urea containing pharmacophore, self-assembles into a hydrogel in the presence of low amounts of solvent. We demonstrate the role of the urea functional group and that of fluorine substitution on the adjacent aromatic ring in promoting self-assembly. We have also shown that linifanib has superior mechanical strength to two structurally related analogues and hence increased potential for localisation at an injection site for drug delivery applications.

Graphical abstract: Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator

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Supplementary files

Article information


Submitted
16 Jan 2015
Accepted
26 Feb 2015
First published
27 Feb 2015

This article is Open Access

Chem. Commun., 2015,51, 6384-6387
Article type
Communication
Author version available

Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator

M. Marlow, M. Al-Ameedee, T. Smith, S. Wheeler and M. J. Stocks, Chem. Commun., 2015, 51, 6384
DOI: 10.1039/C5CC00454C

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