Issue 29, 2015
From the journal:

Chemical Communications

Quantum dot display enhances activity of a phosphotriesterase trimer†

Joyce C. Breger,‡ab   Scott A. Walper,‡a   Eunkeu Oh,cd   Kimihiro Susumu,cd   Michael H. Stewart,c   Jeffrey R. Deschampsa  and  Igor L. Medintz*a  

* Corresponding authors

a Center for Bio/Molecular Science and Engineering, Code 6900, U. S. Naval Research Laboratory, Washington, DC 20375, USA
E-mail: igor.medintz@nrl.navy.mil

b American Society for Engineering Education, Washington, DC 20036, USA

c Optical Sciences Division, Code 5600. U.S. Naval Research Laboratory, Washington, DC 20375, USA

d Sotera Defense Solutions, Columbia, MD 21046, USA

Abstract

Phosphotriesterase was engineered into a spontaneously forming trimer by appending it to a synthetic collagen-like triple-helix motif. Enzymatic hydrolysis of the insecticide and organophosphate nerve agent simulant paraoxon was then examined. Assembling the phosphotriesterase trimer onto semiconductor quantum dots increased the enzyme's catalytic rate and efficiency.

Graphical abstract: Quantum dot display enhances activity of a phosphotriesterase trimer

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5CC00418G
Article type
Communication
Submitted
15 Jan 2015
Accepted
02 Mar 2015
First published
13 Mar 2015

Chem. Commun., 2015,51, 6403-6406

Permissions

Request permissions

Quantum dot display enhances activity of a phosphotriesterase trimer

J. C. Breger, S. A. Walper, E. Oh, K. Susumu, M. H. Stewart, J. R. Deschamps and I. L. Medintz, Chem. Commun., 2015, 51, 6403 DOI: 10.1039/C5CC00418G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements