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Issue 23, 2015
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Enzyme transformation to modulate the ligand–receptor interactions between small molecules

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Abstract

Enzymatic transformation is a fundamental process to control ligand–receptor interactions among proteins for signal transduction in cells. Here we report the first example of enzymatic transformation regulated ligand–receptor interactions of small molecules, in which enzymatic reaction changes the stoichiometry of the ligand–receptor binding from 1 : 1 to 1 : 2. We also show that this unique integration of enzymatic transformation and ligand–receptor interactions of small molecules is able to affect the fate of cells.

Graphical abstract: Enzyme transformation to modulate the ligand–receptor interactions between small molecules

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Article information


Submitted
28 Dec 2014
Accepted
12 Feb 2015
First published
12 Feb 2015

Chem. Commun., 2015,51, 4899-4901
Article type
Communication

Enzyme transformation to modulate the ligand–receptor interactions between small molecules

J. Shi, X. Du, D. Yuan, R. Haburcak, D. Wu, N. Zhou and B. Xu, Chem. Commun., 2015, 51, 4899
DOI: 10.1039/C4CC10374B

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