Chiral N,N′-dioxide–In(OTf)3-catalyzed asymmetric vinylogous Mukaiyama aldol reactions

Abstract

Chiral N,N′-dioxide–In(OTf)₃ complexes were developed as efficient catalysts to catalyze the vinylogous Mukaiyama aldol reaction of the silyl dienol ester with aldehydes. The corresponding δ-hydroxy-α,β-unsaturated esters were obtained in up to 99% yield and 98% ee. Moreover, the obtained (R)-3v can be easily transformed to natural bioactive products.