Guanidinium-pendant oligofluorene for rapid and specific identification of antibiotics with membrane-disrupting ability

Hui Chen; Bing Wang; Jiangyan Zhang; Chenyao Nie; Fengting Lv; Libing Liu; Shu Wang

doi:10.1039/C4CC09729G

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Guanidinium-pendant oligofluorene for rapid and specific identification of antibiotics with membrane-disrupting ability†

Hui Chen,^a Bing Wang,

^a Jiangyan Zhang,^a Chenyao Nie,^a Fengting Lv,*^a Libing Liu^a and Shu Wang*^a

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* Corresponding authors

^a Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, P. R. China
E-mail: wangshu@iccas.ac.cn, lvft@iccas.ac.cn
Fax: +86 10 6263 6680
Tel: +86 10 6263 6680

Abstract

A new method was developed through an efficient Förster resonance energy transfer (FRET) from guanidinium-pendant oligofluorene to green fluorescent protein (GFP) for specifically screening membrane-disrupting antibiotics to which bacteria have difficulty developing resistance.

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Article information

DOI: https://doi.org/10.1039/C4CC09729G
Article type: Communication
Submitted: 05 Dec 2014
Accepted: 22 Jan 2015
First published: 22 Jan 2015

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Chem. Commun., 2015,51, 4036-4039

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Guanidinium-pendant oligofluorene for rapid and specific identification of antibiotics with membrane-disrupting ability

H. Chen, B. Wang, J. Zhang, C. Nie, F. Lv, L. Liu and S. Wang, Chem. Commun., 2015, 51, 4036 DOI: 10.1039/C4CC09729G

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Chemical Communications

Guanidinium-pendant oligofluorene for rapid and specific identification of antibiotics with membrane-disrupting ability†

Abstract

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Guanidinium-pendant oligofluorene for rapid and specific identification of antibiotics with membrane-disrupting ability

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