Issue 14, 2015
From the journal:

Chemical Communications

Pillar[5]arene based supramolecular prodrug micelles with pH induced aggregate behavior for intracellular drug delivery†

Yin Wang,a   Jianwei Du,a   Youxiang Wang,a   Qiao Jin*a  and  Jian Ji*a  

* Corresponding authors

a MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
E-mail: jinqiao@zju.edu.cn, jijian@zju.edu.cn
Fax: +86-571-87953729
Tel: +86-571-87953729

Abstract

A novel type of dual pH-responsive supramolecular prodrug micelles based on host–guest interactions of water-soluble pillar[5]arene (WP5) and methyl viologen functioned doxorubicin (MV-DOX) was prepared. It was found that the prodrug micelles could be aggregated upon acidic condition, which led to enhanced accumulation and better therapy effect.

Graphical abstract: Pillar[5]arene based supramolecular prodrug micelles with pH induced aggregate behavior for intracellular drug delivery

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Article information

DOI
https://doi.org/10.1039/C4CC09274K
Article type
Communication
Submitted
20 Nov 2014
Accepted
02 Jan 2015
First published
19 Jan 2015

Chem. Commun., 2015,51, 2999-3002

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Pillar[5]arene based supramolecular prodrug micelles with pH induced aggregate behavior for intracellular drug delivery

Y. Wang, J. Du, Y. Wang, Q. Jin and J. Ji, Chem. Commun., 2015, 51, 2999 DOI: 10.1039/C4CC09274K

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