The first 2IB,3IA-heterodifunctionalized β-cyclodextrin derivatives as artificial enzymes

S. Letort; D. Mathiron; T. Grel; C. Albaret; S. Daulon; F. Djedaïni-Pilard; G. Gouhier; F. Estour

doi:10.1039/C4CC09189B

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

The first 2^IB,3^IA-heterodifunctionalized β-cyclodextrin derivatives as artificial enzymes†

S. Letort,^a D. Mathiron,^b T. Grel,^a C. Albaret,^c S. Daulon,^c F. Djedaïni-Pilard,^d G. Gouhier^a and F. Estour*^a

Author affiliations

* Corresponding authors

^a Normandie Université, COBRA, UMR 6014 et FR 3038, Université de Rouen, INSA de Rouen, CNRS, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex, France
E-mail: francois.estour@univ-rouen.fr

^b Plate-Forme Analytique, Université de Picardie Jules Verne, 33 rue Saint Leu, 80039 Amiens, France

^c DGA Maîtrise NRBC, Département Evaluation des effets des agents chimiques, 91710 Vert le Petit, France

^d Laboratoire des Glucides, FRE 3517 CNRS, Université de Picardie Jules Verne, 33 rue Saint Leu, F-80033 Amiens, France

Abstract

Novel 2,3-heterodisubstituted β-cyclodextrin derivatives were designed as artificial enzymes to degrade chemical warfare agents. One of them reduced the acetylcholinesterase inhibitory potential by soman faster than its monosubstituted analog.

Download options Please wait...

Supplementary files

Supplementary information PDF (1277K)

Article information

DOI: https://doi.org/10.1039/C4CC09189B
Article type: Communication
Submitted: 18 Nov 2014
Accepted: 18 Dec 2014
First published: 18 Dec 2014

Download Citation

Chem. Commun., 2015,51, 2601-2604

Author version available

Download author version (PDF)

Permissions

Request permissions

The first 2^IB,3^IA-heterodifunctionalized β-cyclodextrin derivatives as artificial enzymes

S. Letort, D. Mathiron, T. Grel, C. Albaret, S. Daulon, F. Djedaïni-Pilard, G. Gouhier and F. Estour, Chem. Commun., 2015, 51, 2601 DOI: 10.1039/C4CC09189B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications