Issue 13, 2015
From the journal:

Chemical Communications

The X-ray structure of the primary adducts formed in the reaction between cisplatin and cytochrome c†

Giarita Ferraro,a   Luigi Messorib  and  Antonello Merlino*ac  

* Corresponding authors

a Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cintia, Napoli, Italy
E-mail: antonello.merlino@unina.it
Fax: +39 081674090
Tel: +39 081674276

b Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy

c CNR Institute of Biostructures and Bioimages, Via Mezzocannone 16, Napoli, Italy

Abstract

In the present study, the interactions between cisplatin and cytochrome c are investigated. Based on high-resolution X-ray diffraction data, two monometalated species, i.e. cyt c–Pt(NH3)2 and cyt c–Pt(NH3)2Cl, are found to be the main adducts that form in the reaction between the protein and the drug. Both monodentate and bidentate platinum coordination to the protein is observed, with platinum binding either to Met65 or to Met65 and Glu61, simultaneously.

Graphical abstract: The X-ray structure of the primary adducts formed in the reaction between cisplatin and cytochrome c

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Article information

DOI
https://doi.org/10.1039/C4CC09056J
Article type
Communication
Submitted
13 Nov 2014
Accepted
23 Dec 2014
First published
23 Dec 2014

Chem. Commun., 2015,51, 2559-2561

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The X-ray structure of the primary adducts formed in the reaction between cisplatin and cytochrome c

G. Ferraro, L. Messori and A. Merlino, Chem. Commun., 2015, 51, 2559 DOI: 10.1039/C4CC09056J

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