Issue 13, 2015
From the journal:

Chemical Communications

An easy-to-detect nona-arginine peptide for epidermal targeting†

Sylvain Clède,a   Nicolas Delsuc,a   Cécile Laugel,b   François Lambert,a   Christophe Sandt,c   Arlette Baillet-Guffroyb  and  Clotilde Policar*a  

* Corresponding authors

a Ecole Normale Supérieure-PSL Research University, Département de Chimie, Sorbonne Universités – UPMC Univ Paris 06, UMR 7203 CNRS-ENS-UPMC LBM, 24, rue Lhomond, 75005 Paris, France
E-mail: clotilde.policar@ens.fr

b Laboratory of Analytical Chemistry, Analytical Chemistry Group of Paris-Sud (GCAPS-EA 4041), Faculty of Pharmacy, University Paris-Sud, 5 Rue Jean-Baptiste Clément, 92296 Chatenay-Malabry, France

c Smis beamline, Synchrotron SOLEIL Saint-Aubin, Gif-sur-Yvette Cedex, France

Abstract

A correlative approach combining synchrotron radiation based IR microscopy and fluorescence microscopy enabled the successful detection and quantification of a nona-arginine peptide labelled with a Single Core Multimodal Probe for Imaging (SCoMPI) in skin biopsies. The topical penetration of the conjugate appeared to be time dependent and occurred most probably via the extracellular matrix.

Graphical abstract: An easy-to-detect nona-arginine peptide for epidermal targeting

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Article information

DOI
https://doi.org/10.1039/C4CC08737B
Article type
Communication
Submitted
25 Nov 2014
Accepted
22 Dec 2014
First published
22 Dec 2014

Chem. Commun., 2015,51, 2687-2689

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An easy-to-detect nona-arginine peptide for epidermal targeting

S. Clède, N. Delsuc, C. Laugel, F. Lambert, C. Sandt, A. Baillet-Guffroy and C. Policar, Chem. Commun., 2015, 51, 2687 DOI: 10.1039/C4CC08737B

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