Issue 10, 2015

Palladium-catalyzed oxidative carbonylation of hydrazides: synthesis of 1,3,4-oxadiazol-2(3H)-ones

Abstract

A novel palladium-catalyzed oxidative carbonylation reaction was developed via the carbon monoxide insertions between the amine group and the carbonyl group to realize the intramolecular cyclization, which provides efficient access to 1,3,4-oxadiazol-2(3H)-ones with a wide range of substrates under mild conditions, resulting in good to excellent yields.

Graphical abstract: Palladium-catalyzed oxidative carbonylation of hydrazides: synthesis of 1,3,4-oxadiazol-2(3H)-ones

Supplementary files

Article information

Article type
Communication
Submitted
03 Nov 2014
Accepted
06 Dec 2014
First published
08 Dec 2014

Chem. Commun., 2015,51, 1905-1907

Author version available

Palladium-catalyzed oxidative carbonylation of hydrazides: synthesis of 1,3,4-oxadiazol-2(3H)-ones

Y. Wang, X. Meng, Y. Yang, L. Zhang, S. Guo, D. Tang, Y. Li and B. Chen, Chem. Commun., 2015, 51, 1905 DOI: 10.1039/C4CC08731C

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