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Issue 6, 2015
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Iron catalyzed oxidative assembly of N-heteroaryl and aryl metal reagents using oxygen as an oxidant

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Abstract

An equivalent amount of N-heteroaryl and aryl Grignard or lithium reagents, after mediation by an equivalent of titanate, was facilely coupled to furnish N-heteroaryl–aryl compounds under the catalysis of FeCl3/TMEDA at ambient temperature using oxygen as an oxidant. Most of the common N-heteroaryls were all good candidates, and thus provided a general, green and pratical protocol for the flexible construction of various N-heteroaryl–aryl structures.

Graphical abstract: Iron catalyzed oxidative assembly of N-heteroaryl and aryl metal reagents using oxygen as an oxidant

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Article information


Submitted
28 Oct 2014
Accepted
24 Nov 2014
First published
25 Nov 2014

Chem. Commun., 2015,51, 1124-1127
Article type
Communication
Author version available

Iron catalyzed oxidative assembly of N-heteroaryl and aryl metal reagents using oxygen as an oxidant

K. M. Liu, L. Y. Liao and X. F. Duan, Chem. Commun., 2015, 51, 1124
DOI: 10.1039/C4CC08494B

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