Yohan Dudognon, Haiying Du, Jean Rodriguez, Xavier Bugaut and Thierry Constantieux
Chem. Commun., 2015,51, 1980-1982
DOI:
10.1039/C4CC08469A,
Communication
We have developed the first multicomponent synthesis of enantioenriched polycyclic 1,2,3,4-tetrahydropyridines bearing three contiguous stereogenic centers under iminium activation. The key to the success of this reaction was the use of polyfunctional substrates including 2-aminophenols and scarcely used β-ketoamides triggering a thermodynamically controlled regio- and diastereoselective sequence.
