Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces

Joe E. Baio; Denise Schach; Adrian V. Fuchs; Lars Schmüser; Nils Billecke; Christoph Bubeck; Katharina Landfester; Mischa Bonn; Michael Bruns; Clemens K. Weiss; Tobias Weidner

doi:10.1039/C4CC07278B

Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces†

Joe E. Baio,‡§^a Denise Schach,‡¶^a Adrian V. Fuchs,^a Lars Schmüser,^a Nils Billecke,^a Christoph Bubeck,^a Katharina Landfester,^a Mischa Bonn,^a Michael Bruns,^b Clemens K. Weiss^ac and Tobias Weidner*^a

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* Corresponding authors

^a Max Planck Institute for Polymer Research, 55270 Mainz, Germany
E-mail: weidner@mpip-mainz.mpg.de

^b Karlsruhe Institute of Technology, Institute for Applied Materials and Karlsruhe Nano Micro Facility, 76344 Eggenstein-Leopoldshafen, Germany

^c University of Applies Sciences Bingen, 55411 Bingen, Germany

Abstract

pH-sensitive viral fusion protein mimics are widely touted as a promising route towards site-specific delivery of therapeutic compounds across lipid membranes. Here, we demonstrate that a fusion protein mimic, designed to achieve a reversible, pH-driven helix-coil transition mechanism, retains its functionality when covalently bound to a surface.

Chemical Communications

Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces†

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Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces

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