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Issue 7, 2015
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Redox-responsive self-assembled chain-shattering polymeric therapeutics

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Abstract

We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via “Click” reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.

Graphical abstract: Redox-responsive self-assembled chain-shattering polymeric therapeutics

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Article information


Submitted
22 Dec 2014
Accepted
03 Feb 2015
First published
13 Feb 2015

Biomater. Sci., 2015,3, 1061-1065
Article type
Communication

Redox-responsive self-assembled chain-shattering polymeric therapeutics

K. Cai, J. Yen, Q. Yin, Y. Liu, Z. Song, S. Lezmi, Y. Zhang, X. Yang, W. G. Helferich and J. Cheng, Biomater. Sci., 2015, 3, 1061
DOI: 10.1039/C4BM00452C

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