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Issue 20, 2015
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Simple and rapid determination of loratadine in pharmaceuticals using square-wave voltammetry and a cathodically pretreated boron-doped diamond electrode

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Abstract

The electrochemical behavior and determination of antihistaminic drug loratadine using a cathodically pretreated boron-doped diamond electrode (BDDE) are proposed. This is the first voltammetric method using a carbon-based electrode material. The anodic peak potential for loratadine at the BDDE was 1.67 V (vs. Ag/AgCl (3.0 mol L−1 KCl)) by cyclic voltammetry in a 0.50 mol L−1 HClO4 solution, whereas at the glassy carbon electrode (GCE), no peak potential was observed, due to the narrow potential window of this electrode. Using the square-wave voltammetric technique (f = 50 Hz, a = 40 mV and ΔES = 2 mV), the obtained analytical curve was linear for loratadine concentrations ranging from 0.98 to 19 μmol L−1. This simple, rapid and green analytical method was successfully applied to the determination of loratadine in pharmaceutical formulations. The results were in close agreement, with a 95% confidence level, with those obtained using comparative spectrophotometric method.

Graphical abstract: Simple and rapid determination of loratadine in pharmaceuticals using square-wave voltammetry and a cathodically pretreated boron-doped diamond electrode

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Article information


Submitted
11 Jul 2015
Accepted
18 Aug 2015
First published
20 Aug 2015

Anal. Methods, 2015,7, 8697-8703
Article type
Paper

Simple and rapid determination of loratadine in pharmaceuticals using square-wave voltammetry and a cathodically pretreated boron-doped diamond electrode

A. P. P. Eisele and E. R. Sartori, Anal. Methods, 2015, 7, 8697
DOI: 10.1039/C5AY01804H

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