A novel photoelectrochemical aptasensor based on the modulation of a dye sensitized TiO2 photoelectrode

Abstract

An N719 dye labeled short DNA chain is introduced onto the surface of a TiO₂ photoelectrode by hybridizing with a pre-immobilized thrombin aptamer to enhance the photocurrent response. After incubating with thrombin, both the dye labeled chain releasing from the photoelectrode and the bound thrombin blocking the electron transfer resulted in a decreased photocurrent.