Issue 10, 2015
From the journal:

Analytical Methods

A long-wavelength fluorescent turn-on probe for video detection of biological thiols in living cells†

Wenqing Jiang,a   Hua Chen,a   Yue Pana  and  Weiying Lin*ab  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, China
E-mail: Weiyinglin2013@163.com

b Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Biological Science and Technology, University of Jinan, Jinan, Shandong 250022, P. R. China

Abstract

We have designed and synthesized the compound FR-thiol based on a new far-red platform as a turn-on fluorescent probe for biological thiols. The turn-on probe FR-thiol displayed a high selectivity and sensitivity to thiols. Finally, we have demonstrated that FR-thiol is suitable for video observation of biological thiols in living cells.

Graphical abstract: A long-wavelength fluorescent turn-on probe for video detection of biological thiols in living cells

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Article information

DOI
https://doi.org/10.1039/C5AY00737B
Article type
Paper
Submitted
19 Mar 2015
Accepted
11 Apr 2015
First published
13 Apr 2015

Anal. Methods, 2015,7, 4168-4172

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A long-wavelength fluorescent turn-on probe for video detection of biological thiols in living cells

W. Jiang, H. Chen, Y. Pan and W. Lin, Anal. Methods, 2015, 7, 4168 DOI: 10.1039/C5AY00737B

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