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Issue 11, 2015
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Pharmacological and therapeutic properties of new derivatives of renin inhibitors and endothelin receptor antagonists, and the methods of their determination

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Abstract

According to data from the World Health Organization, cardiovascular diseases are the most common diseases of the 21st century. They are the reason for about 17 million deaths each year, including 9.4 million deaths caused by hypertensive disease or complications occurring during its course [http://www.thehealthwell.info/node/466541]. Therapeutic schemes in arterial hypertension include monotherapy or combination therapy involving administration of two or three drugs from various pharmacological groups, one of which should exhibit diuretic activity [Hypertension, 2003, 42, 1206–1252]. This review presents new information concerning analytical methods used in order to determine new substances of hypotensive activity belonging to two pharmacological groups, i.e., renin inhibitors and endothelin receptor antagonists.

Graphical abstract: Pharmacological and therapeutic properties of new derivatives of renin inhibitors and endothelin receptor antagonists, and the methods of their determination

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Publication details

The article was received on 12 Mar 2015, accepted on 05 Apr 2015 and first published on 17 Apr 2015


Article type: Critical Review
DOI: 10.1039/C5AY00651A
Anal. Methods, 2015,7, 4419-4442

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    Pharmacological and therapeutic properties of new derivatives of renin inhibitors and endothelin receptor antagonists, and the methods of their determination

    M. Stolarczyk, A. Apola, A. Maślanka and J. Krzek, Anal. Methods, 2015, 7, 4419
    DOI: 10.1039/C5AY00651A

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