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Issue 4, 2015
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Chemical identification of cannabinoids in street marijuana samples using electrospray ionization FT-ICR mass spectrometry

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Abstract

The Cannabis sativa L. plant is a species rich in a variety of cannabinoid compounds and Δ9-tetrahydrocannabinol (Δ9-THC) has been reported as a main psychotropic substance. In this study, electrospray ionization (ESI), coupled with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), was used in order to perform a direct and fast analysis of street marijuana samples. ESI(−)-FT-ICR MS detected 21 cannabinoid species in the deprotonated form, [M − H]. Other species were detected in regions of m/z 600–800 and 800–1000, corresponding to dimers and trimers of cannabinoids. In addition, ESI(−) was better able to analyze the chemical profile of terpenophenolic species (CcHhOo) than ESI(+). ESI(+)-FT-ICR MS detected the presence of adulterants such as cocaine, lidocaine, and nicotine. Finally, the sensitivity of fast blue B colorimetric testing was also evaluated and the results were compared to the ESI(−)FT-ICR MS data.

Graphical abstract: Chemical identification of cannabinoids in street marijuana samples using electrospray ionization FT-ICR mass spectrometry

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Supplementary files

Article information


Submitted
04 Oct 2014
Accepted
26 Dec 2014
First published
02 Jan 2015

Anal. Methods, 2015,7, 1415-1424
Article type
Paper

Chemical identification of cannabinoids in street marijuana samples using electrospray ionization FT-ICR mass spectrometry

I. R. Nascimento, H. B. Costa, L. M. Souza, L. C. Soprani, B. B. Merlo and W. Romão, Anal. Methods, 2015, 7, 1415
DOI: 10.1039/C4AY02355B

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