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Issue 23, 2015
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Real-time reaction monitoring by ultrafast 2D NMR on a benchtop spectrometer

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Abstract

Reaction monitoring is widely used to follow chemical processes in a broad range of application fields. Recently, the development of robust benchtop NMR spectrometers has brought NMR under the fume hood, making it possible to monitor chemical reactions in a safe and accessible environment. However, these low-field NMR approaches suffer from limited resolution leading to strong peak overlaps, which can limit their application range. Here, we propose an approach capable of recording ultrafast 2D NMR spectra on a compact spectrometer and of following in real time reactions in the synthetic chemistry laboratory. This approach – whose potential is shown here on a Heck–Matsuda reaction – is highly versatile; the duration of the measurement can be optimized to follow reactions whose time scale ranges from between a few tens of seconds to a few hours. It makes it possible to monitor complex reactions in non-deuterated solvents, and to confirm in real time the molecular structure of the compounds involved in the reaction while giving access to relevant kinetic parameters.

Graphical abstract: Real-time reaction monitoring by ultrafast 2D NMR on a benchtop spectrometer

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Publication details

The article was received on 28 Sep 2015, accepted on 13 Oct 2015 and first published on 13 Oct 2015


Article type: Communication
DOI: 10.1039/C5AN01998B
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Citation: Analyst, 2015,140, 7854-7858
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    Real-time reaction monitoring by ultrafast 2D NMR on a benchtop spectrometer

    B. Gouilleux, B. Charrier, E. Danieli, J. Dumez, S. Akoka, F. Felpin, M. Rodriguez-Zubiri and P. Giraudeau, Analyst, 2015, 140, 7854
    DOI: 10.1039/C5AN01998B

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