Issue 15, 2015

Highly sensitive determination of reduced glutathione based on a cobalt nanoparticle implanted-modified indium tin oxide electrode

Abstract

Cobalt nanoparticle modified indium tin oxide (CoNP/ITO) electrodes fabricated by ion implantation were applied for the detection of reduced glutathione (GSH). The CoNP/ITO electrode was characterized by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) detector and X-ray photoelectron spectroscopy (XPS). The assay performance with regard to GSH were evaluated by cyclic voltammetry (CV) and chronoamperometry (It). The proposed sensor exhibited a much higher electrocatalytic activity toward the oxidation of GSH than the bare ITO electrode, with a detection limit of 5 nM. The CoNP/ITO electrode showed enhanced electrocatalytic properties, high sensitivity, good long-term stability and reproducibility as well as a rapid response to detect GSH. In addition, the CoNP/ITO electrode was also used to analyse the GSH concentration in eye drop samples, and the results were in good agreement with the labelled values.

Graphical abstract: Highly sensitive determination of reduced glutathione based on a cobalt nanoparticle implanted-modified indium tin oxide electrode

Supplementary files

Article information

Article type
Paper
Submitted
31 Mar 2015
Accepted
15 May 2015
First published
15 May 2015

Analyst, 2015,140, 5176-5183

Highly sensitive determination of reduced glutathione based on a cobalt nanoparticle implanted-modified indium tin oxide electrode

T. Wang, W. Su, Z. Xiao, S. Hao, Y. Li and J. Hu, Analyst, 2015, 140, 5176 DOI: 10.1039/C5AN00631G

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