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Issue 2, 2015
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Photothermal deflectometry enhanced by total internal reflection enables non-invasive glucose monitoring in human epidermis

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Abstract

We present TIR-PTD spectroscopy, an IR-pump/VIS-probe method for the measurement of IR absorption spectra by means of photothermal deflectometry (PTD) enhanced by total internal reflection (TIR). It overcomes the limitations of IR spectroscopy for the study of opaque samples and allows molecular fingerprinting of IR-active liquids or solids. Another important advantage of the presented approach over traditional IR spectroscopy methods is the ability to obtain IR information by means of VIS detection, which is generally much cheaper and easier to handle than IR detection. By application of mid-IR TIR-PTD spectroscopy on human skin in vivo, we are demonstrating the correlation between epidermal- and blood-glucose levels on a type 1 diabetic patient.

Graphical abstract: Photothermal deflectometry enhanced by total internal reflection enables non-invasive glucose monitoring in human epidermis

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Article information


Submitted
01 Jul 2014
Accepted
07 Nov 2014
First published
07 Nov 2014

This article is Open Access

Analyst, 2015,140, 483-488
Article type
Paper
Author version available

Photothermal deflectometry enhanced by total internal reflection enables non-invasive glucose monitoring in human epidermis

M. A. Pleitez, O. Hertzberg, A. Bauer, M. Seeger, T. Lieblein, H. v. Lilienfeld-Toal and W. Mäntele, Analyst, 2015, 140, 483
DOI: 10.1039/C4AN01185F

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