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Issue 21, 2014
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Chitosan-based scaffolds for bone tissue engineering

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Abstract

Bone defects requiring grafts to promote healing are frequently occurring and costly problems in health care. Chitosan, a biodegradable, naturally occurring polymer, has drawn considerable attention in recent years as a scaffolding material in tissue engineering and regenerative medicine. Chitosan is especially attractive as a bone scaffold material because it supports the attachment and proliferation of osteoblast cells as well as formation of mineralized bone matrix. In this review, we discuss the fundamentals of bone tissue engineering and the unique properties of chitosan as a scaffolding material to treat bone defects for hard tissue regeneration. We present common methods for fabrication and characterization of chitosan scaffolds, and discuss the influence of material preparation and addition of polymeric or ceramic components or biomolecules on chitosan scaffold properties such as mechanical strength, structural integrity, and functional bone regeneration. Finally, we highlight recent advances in the development of chitosan-based scaffolds with enhanced bone regeneration capability.

Graphical abstract: Chitosan-based scaffolds for bone tissue engineering

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Publication details

The article was received on 06 Jan 2014, accepted on 04 Mar 2014 and first published on 05 Mar 2014


Article type: Feature Article
DOI: 10.1039/C4TB00027G
Citation: J. Mater. Chem. B, 2014,2, 3161-3184

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    Chitosan-based scaffolds for bone tissue engineering

    S. K. L. Levengood and M. Zhang, J. Mater. Chem. B, 2014, 2, 3161
    DOI: 10.1039/C4TB00027G

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