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Issue 5, 2014
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Water-soluble copolymeric materials: switchable NIR two-photon fluorescence imaging agents for living cancer cells

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Abstract

A simple one-pot multi-component ROMP of hydrophilic, spiropyran (SP) and tert-butyloxycarbonyl-protected (Boc-protected) amino-functionalized norbornenes was developed, and a series of water-soluble copolymeric materials were provided. The photochromic SP moiety endows the copolymers the properties of switchable fluorescence imaging with alternating near-IR (NIR) two-photon and visible single-photon excitations; thereby the copolymers can serve as a promising NIR two-photon fluorescent probe for living cancer cells. The cationic ammonium group enhances the cell transporting capability of the copolymers as well. The present strategy of one-pot ROMP also makes polynorbornene a modular and flexible scaffold in designing and synthesizing specifically biocompatible polymers with applications in imaging, diagnosis and therapy.

Graphical abstract: Water-soluble copolymeric materials: switchable NIR two-photon fluorescence imaging agents for living cancer cells

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Supplementary files

Article information


Submitted
10 Sep 2013
Accepted
26 Oct 2013
First published
29 Oct 2013

J. Mater. Chem. B, 2014,2, 502-510
Article type
Paper

Water-soluble copolymeric materials: switchable NIR two-photon fluorescence imaging agents for living cancer cells

N. Xie, K. Feng, B. Chen, M. Zhao, S. Peng, L. Zhang, C. Tung and L. Wu, J. Mater. Chem. B, 2014, 2, 502
DOI: 10.1039/C3TB21251C

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