Issue 6, 2014

Preparation of core–shell Fe3O4@poly(dopamine) magnetic nanoparticles for biosensor construction

Abstract

Novel core–shell Fe3O4@poly(dopamine) magnetic nanoparticles were prepared through an in situ self-polymerization method. The hybrid nanomaterial showed an average core diameter of 11 ± 3 nm and a polymer thin film thickness of 1.8 ± 0.2 nm. The core–shell nanoparticles were employed as solid supports for the covalent immobilization of horseradish peroxidase (HRP), and the resulting biofunctionalized magnetic nanoparticles were employed to construct an amperometric biosensor for H2O2. The enzyme biosensor showed a high sensitivity of 442.14 mA M−1 cm−2, a low limit of detection of 182 nM, a wide linear range from 6.0 × 10−7 to 8.0 × 10−4 M and high stability for 1 month.

Graphical abstract: Preparation of core–shell Fe3O4@poly(dopamine) magnetic nanoparticles for biosensor construction

Supplementary files

Article information

Article type
Paper
Submitted
21 Aug 2013
Accepted
21 Nov 2013
First published
25 Nov 2013

J. Mater. Chem. B, 2014,2, 739-746

Preparation of core–shell Fe3O4@poly(dopamine) magnetic nanoparticles for biosensor construction

M. Martín, P. Salazar, R. Villalonga, S. Campuzano, J. M. Pingarrón and J. L. González-Mora, J. Mater. Chem. B, 2014, 2, 739 DOI: 10.1039/C3TB21171A

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