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Issue 39, 2014
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Bacteria repelling poly(methylmethacrylate-co-dimethylacrylamide) coatings for biomedical devices

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Abstract

Nosocomial infections due to bacteria have serious implications on the health and recovery of patients in a variety of medical scenarios. Since bacterial contamination on medical devices contributes to the majority of nosocomical infections, there is a need for redesigning the surfaces of medical devices, such as catheters and tracheal tubes, to resist the binding of bacteria. In this work, polyurethanes and polyacrylates/acrylamides, which resist binding by the major bacterial pathogens underpinning implant-associated infections, were identified using high-throughput polymer microarrays. Subsequently, two ‘hit’ polymers, PA13 (poly(methylmethacrylate-co-dimethylacrylamide)) and PA515 (poly(methoxyethylmethacrylate-co-diethylaminoethylacrylate-co-methylmethacrylate)), were used to coat catheters and substantially shown to decrease binding of a variety of bacteria (including isolates from infected endotracheal tubes and heart valves from intensive care unit patients). Catheters coated with polymer PA13 showed up to 96% reduction in bacteria binding in comparison to uncoated catheters.

Graphical abstract: Bacteria repelling poly(methylmethacrylate-co-dimethylacrylamide) coatings for biomedical devices

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Supplementary files

Article information


Submitted
10 Jul 2014
Accepted
19 Aug 2014
First published
02 Sep 2014

This article is Open Access

J. Mater. Chem. B, 2014,2, 6723-6729
Article type
Paper
Author version available

Bacteria repelling poly(methylmethacrylate-co-dimethylacrylamide) coatings for biomedical devices

S. Venkateswaran, M. Wu, P. J. Gwynne, A. Hardman, A. Lilienkampf, S. Pernagallo, G. Blakely, D. G. Swann, M. P. Gallagher and M. Bradley, J. Mater. Chem. B, 2014, 2, 6723
DOI: 10.1039/C4TB01129E

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