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Issue 34, 2014
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Facile preparation of gadolinium(iii) chelates functionalized carbon quantum dot-based contrast agent for magnetic resonance/fluorescence multimodal imaging

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Abstract

Suffering from high inherent toxicity generated from heavy metals in semiconductor quantum dots and a complex preparation process, the medical application of conventional gadolinium(III)/semiconductor quantum dot-based magnetic resonance/fluorescence multimodal imaging (MRI/FI) contrast agent has been limited. In this paper, a new kind of biocompatible carbon quantum dot functionalized by gadolinium(III) chelates (named as Gd(III)/CQDs) was obtained through one-step pyrolysis of gadopentetate monomeglumine, which provides simultaneously a carbon source and a gadolinium(III) source. The Gd(III)/CQDs show good magnetic resonance response and photoluminescence properties with longitudinal relaxation rate and quantum yield of 5.5–6.4 mM L−1 S−1 [Gd(III)%, 0.5 mM] and 2.6–8.9%, respectively. The Gd(III)/CQDs with diameters in the range of 2–3 nm can be well dispersed in deionized water, phosphate-buffered saline buffer solution or culture medium to form a stable dispersion, which with low cytotoxicity can penetrate into cells and show green fluorescence (excitation at 488 nm), presenting a great potential to be used as an MRI/FI contrast agent.

Graphical abstract: Facile preparation of gadolinium(iii) chelates functionalized carbon quantum dot-based contrast agent for magnetic resonance/fluorescence multimodal imaging

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Supplementary files

Article information


Submitted
04 May 2014
Accepted
23 Jun 2014
First published
24 Jun 2014

J. Mater. Chem. B, 2014,2, 5541-5549
Article type
Paper
Author version available

Facile preparation of gadolinium(III) chelates functionalized carbon quantum dot-based contrast agent for magnetic resonance/fluorescence multimodal imaging

X. Ren, L. Liu, Y. Li, Q. Dai, M. Zhang and X. Jing, J. Mater. Chem. B, 2014, 2, 5541
DOI: 10.1039/C4TB00709C

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